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茵陳蒿湯之抗氧化作用的研究

我们在过去的研究中发现，十二種常用保肝中药方剂中以茵陳蒿湯的抗氧化活性最为明显。由于茵陳蒿湯经常被使用于治疗急性肝炎，因此，本研究进一步观察茵陳蒿湯对急性肝炎患者之全血超氧陰离子(O₂)及过氧化氢(H₂O₂)之清除作用，并進一步探讨茵陳蒿湯的组成三種中药大黄、茵陳蒿及槴子之抗氧化作用。结果發现，茵陳蒿湯水萃取物可以顯著地清除急性肝炎患者全血中的超氧陰离子及过氧化氢，但以清除超氧陰离子的作用較明顯。另一方面，茵陳蒿湯的三種组成生药大黄、茵陳蒿、槴子之水萃取物都具有清除由黄嘌呤/黄嘌呤氧化脢产生之超氧陰离子的作用，并且能抑制氯化亚铁诱发大白鼠肝细胞脂质过氧化，三種中药的抗氧化活性中以大黄最为显著。由以上结果顯示，茵陳蒿湯能有效地清除急性肝炎患者全血中之氧自由基，而三種组成中药中又以大黄为最强的抗氧化剂。

　　關键词：茵陳蒿湯，抗氧化作用，急性肝炎，超氧陰离子，过氧化氢，过氧化脂

The study on the antioxidative effect of yin chen hao tang

　　Organization: Tainan Municipal Hospital

　　Auther: Ming-feng Chen

　　In our previous study, we found that Inchenhau-Tang(ICHT) is a most strong anti-oxidant among twelve herb drug prescriptions which are popularly used in treatment of liver disease. ICHT is mostly used in treatment of acute hepatitis with jaundice. Therefore, in this study we further investigated the scavenging effect of ICHT on the oxygen radicals including superoxide anion(O2() and hydrogen peroxide(H2O2) in the whole blood of patients with acute hepatitis. On the other hand, we also investigated the anti-oxidative effect of Artemisiae Capillaris Herba(ACH), Gardeniae Fructus(GF), and Rhei Rhizoma(RR) which are composed of ICHT. The results show that, the watery extract of ICHT significantly scavenged both superoxide anion and hydrogen peroxide in the whole blood of patients with acute hepatitis. The scavenging effect of ICHT on superoxide anion was greater than that on hydrogen peroxide. On the other hand, all of watery extracts of three composed herb drugs significantly scavenged superoxide anion produced by xanthine/xanthine oxidase, and markedly inhibited the production of lipid peroxide from rat liver cells induced by FeCl2. Among them, RR had most strong anti-oxidative effect. The above results revealed that watery extract of ICHT can scavenge oxygen radicals in the whole blood of patients with acute hepatitis. Among three composed herb drugs of ICHT, RR is a most important antioxidant.

　　Key words: Inchenhau-Tang, antioxidative effect, acute hepatitis, superoxide anion, hydrogen peroxide, lipid peroxide

Annotated by:  Joe Hing kwok Chu

Inchenhau-Tang(ICHT): yin chen hao tang